Downs Syndr Res Pract. 2001 Jul;6(3):139-45.
Downs Syndr Res Pract 2002 Mar;8(1):37.
The relation between the psychological functioning of children with Down syndrome and their urine peptide levels and levels of serum antibodies to food proteins.
0. Nygaard E, Reichelt KL, Fagan JF.
University of Oslo, Norway. Denne e-postadressen er beskyttet mot programmer som samler e-postadresser. Du må aktivere javaskript for å kunne se den.
AIMS: To investigate the relation between psychological functioning of subjects with Down syndrome, and their levels of urine peptide and serum antibodies to food proteins. METHODS: 55 children with Down syndrome in a cross-sectional study. Psychological functioning was measured by the Stanford-Binet Intelligence Scale: Fourth Edition, McCarthy Scales of Children's Abilities and Fagan's computer based test of novelty preference. RESULTS: The participants, and their siblings, were found to have significantly increased total urine peptide levels. There were no significant correlations between peptide levels and psychological functioning. Significantly increased levels of IgG activity to gliadin and gluten, and IgA activity to gliadin, gluten and casein were found. There were significant negative correlations (Spearman r = -0.13 to -0.51) between psychological functioning, and IgG and IgA activity to gliadin and gluten. CONCLUSIONS: A significant relation between antibodies to gluten and psychological functioning was documented. The mechanism and potential causal link are still unknown.
PMID: 11501218 [PubMed - indexed for MEDLINE]
1: Acta Paediatr Jpn. 1994 Oct;36(5):489-92.
Increased levels of antibodies to food proteins in Down syndrome.
0. Reichelt KL, Lindback T, Scott H.
Department of Pediatric Research, National Hospital, Rikshospitalet, Oslo, Norway.
An increased level of immunoglobulin A (IgA) antibodies to food antigens has been found in Down syndrome. Biopsy did not show any anomaly of the gut. Increased IgA levels against specific proteins reflect increased transmucosal transport of antigens. The antigens presented may be immunogenic peptides or intact antigens. In this paper, we wished to exclude an institutional cause such as infections and also age differences.
PMID: 7825448 [PubMed - indexed for MEDLINE]